Research Program Summary

Currently IMNR has the following research programs up and running:

The LeDoux Lab at New York University is studying how auditory and other external stimuli trigger fight-flight responses by acting in the amygdala. The LeDoux lab has a 40 year history of studying this phenomenon for basic science purposes. Joseph LeDoux is the author of several books including The Emotional Brain and more recently Anxiety, and his work on the amygdala revolutionized the field of neuroscience and how we think about our physiological responses, cognitions, memories and emotions. Studies at the LeDoux lab directly confront the working hypothesis that Misophonia results from the brain misinterpreting repetitious auditory stimuli as dangerous, and therefore triggers fight/flight. Beside being one of the world’s leading neuroscientists, Dr. LeDoux is also a musician and very kind person.   Click LeDoux Lab page for more information or contact jbrout@

Duke University Sensory Processing and Emotion Regulation Program: Founded by Jennifer Jo-Brout in 2008, and led by Vice Chair of Duke Psychiatry Dr. Zach M. Rosenthal, this program investigates the relationship of auditory over-responsivity (Misophonia) with emotions, cognition, and behavior. Current research relates to symptoms of auditory over-responsivity manifesting in psychiatric disorders, and how this may inform our understanding of Misophonia and related problems. In addition, Duke Psychiatry is dedicated to establishing the best practices for mental health therapists working with Misophonia patients in tandem with these patients and their families. As such, “Reason, Regulate, and Reassure” (a self-help coping skills program) will be tested and monitored through Duke Psychiatry. Notably, Dr. Rosenthal was one of the first psychologists to agree to study auditory over-responsivity (Misophonia) in 2008, at a time when most researchers were at best “not interested”, and has kept our program going at times when it was very difficult to do so. Results from the one of the program’s original studies, as well an updated study, are available. Click here for more information about the Duke Program

Stephen Porges at the University Of Chappell Hill NC: Documenting the acoustic features that elicit subjective experiences related to pathogen, predator, danger, and safety. Preliminary results suggest that body sounds have a unique acoustic profile that may trigger hard-wired responses. Dr. Porges is most well known for his Polyvagal theory and has a dedication, specifically to auditory issues, beyond that which most others have. Dr. Porges has worked and continues to work across an extraordinarily wide variety of disciplines with a developmental perspective, bringing to the table an incredibly broad viewpoint, with a specific focus on auditory hypersensitivities.   Click ———- or contact jbrout@